Non-Invasive Ischemia Detector

ACME Non-invasive Ischemia Detector (ACME NID) is a reliable, non-invasive tool for ischemia detection algorithm. It is a patented algorithm that analyzes 10 second 12 lead ECG captured by either our own QED 2000 or a certified off-the-shelf ECG machine, and it aims to assist in detection of myocardial ischemia related to Coronary Artery Disease (CAD).

The ACME NID revolutionizes the field of non-invasive coronary artery disease diagnosis in several ways:


The ACME NID is a high-resolution ECG acquisition hardware, employing a sampling rate of 1000Hz. It uses frequency domain processing to predict ischemia. This process can be broken down into two steps. The first step is Time-frequency operation, which extracts 12 lead ECG signals from J point to T peak and takes the ST segment. The second step uses a logistic regression method to determine the risk of ischemia in the area.

Time-frequency Processing

Step 1: Identify the characteristic points in each beat.

Heartbeat Chart

Step 2: For each beat, isolate the R-peak (or J-point) to T-peak segment. "Stretch" (resample) the segment to a fixed length. Finally, take the average of the fixed length (resampled) RT (or JT) segments. In this study, the discrete length is 512.

Heartbeat Chart 2

Step 3: Take the time-frequency transform of the averaged RT/JT segment to generate spectral harmonics h0, h1, h2, ..., h511.

Spectral Harmonics

Step 4: Pattern Classification.

2.5s of lead V6 (time domain) JTp segment at V6 (time domain) DCT OF JTp segment at V6 (frequency domain)